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Expert care for a wide range of skin conditions, ensuring healthy, radiant skin.
Lesions & Bumps
Comprehensive care for skin lesions and bumps, promoting clear and healthy skin.
Lifting & Tightening
Advanced treatments to lift and lighten the skin, enhancing firmness and brightness.
Rejuvenation
Revitalize your skin with advanced treatments designed to restore a youthful glow.
Skin Treatments
Effective solutions for a variety of skin concerns, promoting clear and healthy skin.
Wellness
Holistic skincare approaches to support overall skin health and well-being.
Advanced, non-invasive treatments to rejuvenate your appearance without surgery.
Body Treatments
Transformative, non-invasive treatments to sculpt and tone your body effortlessly.
Facial Treatments
Rejuvenating facial treatments to refresh and enhance your natural radiance.
Hair Treatments
Advanced treatments to restore hair vitality and promote healthy growth.
Injectables
Minimally invasive injectables to smooth wrinkles and enhance facial contours.
Precision cosmetic surgery tailored to enhance and refine your natural beauty.
Body Surgery
Expertly performed body surgeries to reshape, contour, and enhance your physique.
Breast Surgery
Specialized breast surgeries to enhance shape, size, and symmetry for a natural look.
Cosmetic Andrology
Advanced procedures designed to enhance male aesthetics and address intimate concerns.
Cosmetic Gynaecology
Tailored surgical solutions to enhance feminine aesthetics and improve intimate well-being.
Facial Surgery
Precision facial surgeries to refine features and achieve natural, balanced results.
Fat Transfer/Removal
Advanced fat transfer and removal techniques to sculpt and enhance your body’s contours.
Comprehensive solutions to address a range of body concerns, from stubborn fat to skin laxity.
Breasts
Tailored solutions for breast concerns, including size, shape, and symmetry.
Other Areas
Targeted solutions for stubborn areas of the body, tailored to your unique needs.
Volume & Contouring
Specialized treatments to enhance body volume and improve overall contour for a balanced silhouette.
Holistic care focused on improving overall health and well-being for a balanced lifestyle.
Digestive Health
Comprehensive care to support digestive health and improve overall well-being.
Energy & Immunity
Holistic approaches to boost energy levels and strengthen your immune system for optimal health.
General Health
Personalized strategies to maintain and enhance your overall health and vitality.
Expert care for a wide variety of skin and facial concerns, promoting a healthy, glowing complexion.
Ageing Signs
Expert treatments to minimize ageing signs, rejuvenating your skin for a youthful glow.
Skin Texture & Tone
Advanced treatments to improve skin texture and even out tone for a smoother, radiant complexion.
Specific Areas
Targeted treatments to address skin concerns in specific facial areas for balanced, refined results.
Volume & Contouring
Tailored solutions to restore facial volume and enhance natural contours for a more youthful appearance.
When a friend uses your referral code, they’ll get £50 off their first treatment, and you’ll get £50 off your next one.
The more friends you invite, the more you earn.
What Are Polynucleotides? Definition, Uses & Benefits
Summary
Polynucleotides are natural molecules made from the same building blocks as DNA and RNA. In aesthetic medicine, they are used as injectable treatments that help your skin repair itself, boost collagen production, improve hydration, and restore a healthier, fresher appearance without adding volume or changing your facial shape.
Across the UK, many people are looking for a treatment that improves the skin in a natural and long term way. Some are moving away from treatments that dramatically change how they look. This is exactly where polynucleotides come in.
This treatment works under the surface, and supports your skin’s natural ability to repair, hydrate, and rebuild itself.
Let us keep it simple. Polynucleotides are long chains of tiny molecules called nucleotides. These are the same building blocks that make up your DNA.
So in a way, polynucleotides are something your body already understands very well.
Related read:
To help you understand why polynucleotides are effective, it helps to know what they are made of. Each nucleotide has three parts:
These units join together to form long chains, this is what we call polynucleotide.
In aesthetic medicine, polynucleotides are derived from natural sources, most commonly:
This may surprise you at first, but there is a good reason for it.
These sources are:
Before being used in treatments, the material goes through strict processes:
So what is injected into your skin is clean, safe, and made especially for medical use.
Once polynucleotides are injected into the skin, they begin working at a deeper level. They help to:
They are also often described as regenerative treatments.
Polynucleotides do more than just collagen boosting.
They also:
Over time, this leads to skin that feels:
Polynucleotides have actually been used in medicine long before aesthetics.
They are commonly used in:
One well-known form is PDRN (polydeoxyribonucleotide), which has been studied for its ability to speed up healing and reduce inflammation.
In aesthetics, polynucleotides are delivered through a series of small injections into the skin.
Results rebuild gradually, which is why they look so natural.
In simple terms, polynucleotides are used to improve skin quality, not shape.
They are ideal if you want:
Polynucleotides can be used in several areas, including:
These areas often show early signs of ageing, making them ideal for regenerative treatments.
In simple terms:
They are sometimes combined in a treatment plan to target different concerns.
Related read:
The main benefits are all about improving how your skin looks and feels.
You may notice:
Polynucleotides also help with:
Because they support skin repair, they are a very effective treatment for a wide range of concerns.
This is not a quick fix treatment and it is actually a good thing because results continue to improve over time.
WIth a full course of treatment:
Your practitioner will guide you based on your skin.
Polynucleotides are considered safe and well tolerated, especially when performed by a qualified practitioner.
These side effects settle within a few days.
That is why a proper consultation is always important.
Related read:
There is growing scientific interest in polynucleotides
suggest they can:
(a type of polynucleotide) show that it can support tissue repair and reduce inflammation, both are important for healthier skin.
However, like many aesthetic treatments, research is still evolving.
Future uses of polynucleotides may include:
This is an exciting area of aesthetic medicine that continues to grow.
Polynucleotides could be a very good option if you want a more natural, fresher appearance. It can offer a different approach to skin treatment.
Instead of changing how your face looks, they focus on:
The best way to know if polynucleotides are right for you is through a professional consultation.
A qualified practitioner will:
This is also the time you can ask all the questions you want before scheduling your initial treatment.
today at Harley Street Skin Clinic.
They are made of purified DNA fragments, usually sourced from salmon or trout.
The pain is tolerable according to most people. Numbing cream is used to keep you comfortable.
Results can last several months, especially with maintenance treatments.
Yes. They are suitable for most skin types, but a consultation is still recommended.
PDRN is a type of polynucleotide used in medicine, with in aesthetic treatments, broader formulation may be used.
Reserve a polynucleotides appointment
One of our experts will be more than happy to answer any questions you have.
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Charlene Millen
I had lip filler with Dr Tee, I have very thin lips and he did such a great job! Really natural but a nice, subtle difference.
18th June 2026
Hnisha Patel
Great experience with the staff and doctor. Was quick and easy to book an appt and the doctor was efficient and helpful!
17th June 2026
M Samuel
Amazing staff, helpful and a supportive team.
18th June 2026
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The Harley Street Skin Clinic is an award-winning boutique private cosmetic clinic in the heart of London. We offer the most advanced surgical and non surgical techniques in our fully-fitted consulting rooms, state-of-the-art operating theatres and purpose-built aesthetics and laser suite.
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